The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 11, 2012

Filed:

Jul. 20, 2010
Applicants:

Roch Boivin, Lawrence, MA (US);

Kenichi Chiba, Tsuchiura, JP;

Jesse Chow, Hooksett, NH (US);

Hong Du, North Andover, MA (US);

Yoshihito Eguchi, Kashiwa, JP;

Masanori Fujita, Ushiku, JP;

Masaki Goto, Tsuchiura, JP;

Fabian Gusovsky, Andover, MA (US);

Jean-christophe Harmange, Andover, MA (US);

Atsushi Inoue, Tsukuba, JP;

Yimin Jiang, Londonderry, NH (US);

Megumi Kawada, Ushiku, JP;

Takatoshi Kawai, Tsukuba, JP;

Yoshiyuki Kawakami, Tsukuba, JP;

Akifumi Kimura, Tsukuba, JP;

Makoto Kotake, Abiko, JP;

Yoshikazu Kuboi, Tsukuba, JP;

Charles-andré Lemelin, North Chelmsford, MA (US);

Xiang-yi LI, Andover, MA (US);

Tomohiro Matsushima, Ushiku, JP;

Yoshiharu Mizui, Tsukuba, JP;

Kenzo Muramoto, Tsukuba, JP;

Hideki Sakurai, Tsukuba, JP;

Yong-chun Shen, Tewksbury, MA (US);

Hiroshi Shirota, Belmont, MA (US);

Mark Spyvee, Hampstead, NH (US);

Isao Tanaka, Tsukuba, JP;

John (Yuan) Wang, Andover, MA (US);

Satoshi Yamamoto, Moriya, JP;

Naoki Yoneda, Tsukuba, JP;

Inventors:

Roch Boivin, Lawrence, MA (US);

Kenichi Chiba, Tsuchiura, JP;

Jesse Chow, Hooksett, NH (US);

Hong Du, North Andover, MA (US);

Yoshihito Eguchi, Kashiwa, JP;

Masanori Fujita, Ushiku, JP;

Masaki Goto, Tsuchiura, JP;

Fabian Gusovsky, Andover, MA (US);

Jean-Christophe Harmange, Andover, MA (US);

Atsushi Inoue, Tsukuba, JP;

Yimin Jiang, Londonderry, NH (US);

Megumi Kawada, Ushiku, JP;

Takatoshi Kawai, Tsukuba, JP;

Yoshiyuki Kawakami, Tsukuba, JP;

Akifumi Kimura, Tsukuba, JP;

Makoto Kotake, Abiko, JP;

Yoshikazu Kuboi, Tsukuba, JP;

Charles-André Lemelin, North Chelmsford, MA (US);

Xiang-Yi Li, Andover, MA (US);

Tomohiro Matsushima, Ushiku, JP;

Yoshiharu Mizui, Tsukuba, JP;

Kenzo Muramoto, Tsukuba, JP;

Hideki Sakurai, Tsukuba, JP;

Yong-Chun Shen, Tewksbury, MA (US);

Hiroshi Shirota, Belmont, MA (US);

Mark Spyvee, Hampstead, NH (US);

Isao Tanaka, Tsukuba, JP;

John (Yuan) Wang, Andover, MA (US);

Satoshi Yamamoto, Moriya, JP;

Naoki Yoneda, Tsukuba, JP;

Assignee:

EISAI Co., Ltd., Tokyo, JP;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/355 (2006.01); C07D 313/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention provides methods for the use of compounds having formula (I) in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R-R, t, X, Y, Z, and n are as defined herein.


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