The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 11, 2012
Filed:
Dec. 18, 2006
José Ignacio Andrés-gil, Madrid, ES;
Manuel Jesús Alcázar-vaca, Toledo, ES;
Rosa María Álvarez-escobar, Toledo, ES;
Julen Oyarzabal Santamarina, Olias del Rey (Toledo), ES;
Frank Matthias Dautzenberg, Vosselaar, BE;
Jacqueline Macritchie, Saffron Walden, GB;
Donald Simpson, Haverhill, GB;
Sonia Martinez Gonzalez, Tres Cantos (Madrid), ES;
José Ignacio Andrés-Gil, Madrid, ES;
Manuel Jesús Alcázar-Vaca, Toledo, ES;
Rosa María Álvarez-Escobar, Toledo, ES;
Julen Oyarzabal Santamarina, Olias del Rey (Toledo), ES;
Frank Matthias Dautzenberg, Vosselaar, BE;
Jacqueline Macritchie, Saffron Walden, GB;
Donald Simpson, Haverhill, GB;
Sonia Martinez Gonzalez, Tres Cantos (Madrid), ES;
Janssen Pharmaceutica, N.V., Beerse, BE;
Abstract
The present invention concerns aryl and heteroaryl substituted pyrazinone derivatives having antagonistic melanin-concentrating hormone (MCH) activity, in particular MCH-1 activity according to the general Formula (I) a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof, an N-oxide form thereof or a quaternary ammonium salt thereof, wherein the variables are defined in Claim. It further relates to their preparation, compositions comprising them and their use as a medicine. The compounds according to the invention are useful for the prevention and/or treatment of psychiatric disorders, including but not limited to anxiety, eating disorders, mood disorders, such as bipolar disorders and depression, psychoses, such as schizophrenia, and sleeping disorders; obesity; diabetes; sexual disorders and neurological disorders.