The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 11, 2012
Filed:
Oct. 04, 2004
Vijay K. Kuchroo, Newton, MA (US);
Terry Strom, Brookline, MA (US);
Eugene K. Cha, Muttontown, NY (US);
Sumone Chakravarti, Oakland, CA (US);
Catherine Sabatos, San Francisco, CA (US);
Chen Zhu, Brookline, MA (US);
Xin Xiao Zheng, Wellesley, MA (US);
Alberto Sanchez-fueyo, Barcelona, ES;
Vijay K. Kuchroo, Newton, MA (US);
Terry Strom, Brookline, MA (US);
Eugene K. Cha, Muttontown, NY (US);
Sumone Chakravarti, Oakland, CA (US);
Catherine Sabatos, San Francisco, CA (US);
Chen Zhu, Brookline, MA (US);
Xin Xiao Zheng, Wellesley, MA (US);
Alberto Sanchez-Fueyo, Barcelona, ES;
The Brigham and Women's Hospital, Inc., Boston, MA (US);
Beth Israel Deaconess Medical Center, Inc., Boston, MA (US);
Abstract
The invention relates to isolated polypeptides and nucleic acids encoding polypeptides which comprise a tim-3 IgV domain and a tim-3 intracellular domain, wherein the polypeptides do not comprise a tim-3 mucin domain or a tim-3 transmembrane domain. In addition, the invention relates to methods of modulating immune responses in a subject, comprising administering to the subject a therapeutically effective amount of an agent that modulates tim-3 activity. Immune responses include, but are not limited to, immune tolerance, transplantation tolerance, Th1 responses and Th2 responses.