The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 11, 2012
Filed:
Jul. 18, 2008
Sjoerd Nicolaas Wadman, Welwyn Garden City, GB;
Sjoerd Nicolaas Wadman, Welwyn Garden City, GB;
Novacta Biosystems Limited, Hertfordshire, GB;
Abstract
The present invention provides actagardine, actagradine B and deoxy actagardine B derivatives of formula (I), wherein: X1 denotes that the residue is Leu; Val; or Ile; X2 denotes that the residue is Leu; Val; or Ile; Rrepresents an alkyl or heteroalkyl group, substituted by at least one hydroxyl substituent, and Rrepresents hydrogen, or an alkyl or heteroalkyl group, optionally substituted by at least one hydroxyl substituent, or Rand Rtaken together with the nitrogen atom represent a heterocyclic group having at least one hydroxyl substituent, wherein the heterocyclic group optionally further contains one or more heteroatoms; Z is an amino acid residue, —NRR, —NRCOR, —NRC(O)OR; —NRSOR, NRSOR; —NRC(S)NRR, —NRC(NR)NRR, or —N═R, where R, R, R, R, R, Rand Rare independently hydrogen, or a group, optionally substituted, selected from alkyl, heteroalkyl, aryl, heteroaryl, aralkyl and heteroaralkyl, with the proviso that Ris not hydrogen; and Y is —S— or —S(O)—. The compounds find use in the treatment of microbial infections.