The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 11, 2012
Filed:
Jul. 11, 2008
William C. Powell, Renton, WA (US);
Linda Willoughby Kivi, Marana, AZ (US);
Patrick C. Roche, Tucson, AZ (US);
Gary Gooch, Tucson, AZ (US);
Fabien Gaire, Oro Valley, AZ (US);
William C. Powell, Renton, WA (US);
Linda Willoughby Kivi, Marana, AZ (US);
Patrick C. Roche, Tucson, AZ (US);
Gary Gooch, Tucson, AZ (US);
Fabien Gaire, Oro Valley, AZ (US);
Ventana Medical Systems, Inc., Tucson, AZ (US);
Abstract
Disclosed herein are antigen-binding molecules, such as antibodies, that specifically recognize a portion of the EGFR C-terminal (intracellular) regulatory domain that interacts with one or more regulatory molecules (such as Suppressor of Cytokine Signaling ('SOCS') proteins). In certain normal or neoplastic cells and/or tissues, this region is inaccessible to the disclosed antigen-binding molecules. Thus, such antigen-binding molecules are useful at least to interrogate the regulated state of EGFR, predict the response of a cancer patient to EGFR inhibitor therapies, and/or predict the aggressiveness of neoplasms.