The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 11, 2012
Filed:
Mar. 29, 2007
Osamu Hazeki, Hiroshima, JP;
Kaoru Hazeki, Hiroshima, JP;
Masayuki Ii, Osaka, JP;
Naoko Matsunaga, Osaka, JP;
Osamu Hazeki, Hiroshima, JP;
Kaoru Hazeki, Hiroshima, JP;
Masayuki Ii, Osaka, JP;
Naoko Matsunaga, Osaka, JP;
Hiroshima University, Hiroshima, JP;
Takeda Pharmaceutical Company Limited, Osaka, JP;
Abstract
The present invention provides a method of screening for a drug for the prophylaxis or treatment of at least one disease selected from the group consisting of cardiac disease, autoimmune disease, inflammatory disease, central nervous system disease, infectious disease, sepsis, severe sepsis and septic shock, which includes selecting a substance that binds to an intracellular region of TLR4, and inhibits signal transduction from said molecule, and a kit for this method, which contains (1) a cell that expresses wild-type TLR4 and (2) a cell that expresses a mutant TLR4, and which can detect a signal from TLR4 with expression of a reporter gene as an index.