The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 04, 2012
Filed:
Jan. 10, 2011
Detlef Grawe, Kleinromstedt, DE;
Sabine Gliesing, Jena, DE;
Hagen Gerecke, Jena, DE;
Peter Hoesel, Jena, DE;
Uwe Mueller, Jena, DE;
Thomas Michel, Leipzig, DE;
Robert Eilers, Jena, DE;
Uwe Knabe, Trockenborn, DE;
Bernd Erhart, Kahla, DE;
Michael Mosebach, Berlin, DE;
David Voigtlaender, Bad Vilbel, DE;
Ulf Tilstam, Hoegaarden, BE;
Jürgen Jacke, Unna, DE;
Klaus Bahl, Herne, DE;
Ulf Bohlmann, Köln, DE;
Dieter Wehmeier, Bergkamen, DE;
Michael Sander, Frechen, DE;
Detlef Grawe, Kleinromstedt, DE;
Sabine Gliesing, Jena, DE;
Hagen Gerecke, Jena, DE;
Peter Hoesel, Jena, DE;
Uwe Mueller, Jena, DE;
Thomas Michel, Leipzig, DE;
Robert Eilers, Jena, DE;
Uwe Knabe, Trockenborn, DE;
Bernd Erhart, Kahla, DE;
Michael Mosebach, Berlin, DE;
David Voigtlaender, Bad Vilbel, DE;
Ulf Tilstam, Hoegaarden, BE;
Jürgen Jacke, Unna, DE;
Klaus Bahl, Herne, DE;
Ulf Bohlmann, Köln, DE;
Dieter Wehmeier, Bergkamen, DE;
Michael Sander, Frechen, DE;
Bayer Pharma AG, Berlin, DE;
Abstract
The present invention relates to a method for the reliable and reproducible preparation of 4-[17β-methoxy-17α-methoxymethyl-3-oxoestra-4,9-dien-11β-yl]benzaldehyde (E)-oxime (asoprisnil) on the pilot and manufacturing scale. Asoprisnil, which is prepared by this method, is distinguished by a very good physical stability and is therefore particularly suitable for the manufacture of solid pharmaceutical forms (tablets, coated tablets, etc.).