The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 04, 2012
Filed:
Oct. 20, 2009
David Robert Bolin, Montclair, NJ (US);
Adrian Wai-hing Cheung, Glen Rock, NJ (US);
Matthew Michael Hamilton, Hackettsown, NJ (US);
Nicholas Marcopulos, North Caldwell, NJ (US);
Lee Apostle Mcdermott, East Windsor, NJ (US);
Yimin Qian, Wayne, NJ (US);
David Robert Bolin, Montclair, NJ (US);
Adrian Wai-Hing Cheung, Glen Rock, NJ (US);
Matthew Michael Hamilton, Hackettsown, NJ (US);
Nicholas Marcopulos, North Caldwell, NJ (US);
Lee Apostle McDermott, East Windsor, NJ (US);
Yimin Qian, Wayne, NJ (US);
Madrigal Pharmaceuticals, Inc., Fort Washington, PA (US);
Abstract
Provided herein are compounds of the formula (I): were RI is phenyl, R2 is hydrogen, halogen or lower alkyl, X is carbon on nitrogen, and R3 is isoquinoline, -amino, or a -4- to 6-membered heterocycloalkyl ring and pharmaceutically acceptable salts thereof, which are active as DGAT inhibitors and therefore find uses in treatment of diseases associated with abnormal metabolism of trigliceride. such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.