The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 04, 2012
Filed:
Aug. 29, 2008
Richard Frederic Borch, Lafayette, IN (US);
Richard Anthony Gibbs, West Lafayette, IN (US);
Michelle Martin Clark, Overland Park, KS (US);
Farid Fouad, Youngstown, OH (US);
Richard Frederic Borch, Lafayette, IN (US);
Richard Anthony Gibbs, West Lafayette, IN (US);
Michelle Martin Clark, Overland Park, KS (US);
Farid Fouad, Youngstown, OH (US);
Purdue Research Foundation, West Lafayette, IN (US);
Abstract
Described herein are neutral prodrugs of phosphorus-containing inhibitors of farnesyl transferase that include one or more phosphate fragments or analogs of phosphate fragments. Analogs of phosphate fragments include various linkers other than oxygen connecting the phosphate fragment to the remaining portion of the drug, such as but not limited to linkers forming phosphoramidates, phosphonates, difluorophosphonates, phosphordiamidates, and the like.