The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 04, 2012
Filed:
Apr. 29, 2009
Applicants:
Akin Akinc, Needham, MA (US);
Tomoko Nakayama, Cambridge, MA (US);
Muthiah Manoharan, Weston, MA (US);
Markus Stoffel, New York, NY (US);
Inventors:
Akin Akinc, Needham, MA (US);
Tomoko Nakayama, Cambridge, MA (US);
Muthiah Manoharan, Weston, MA (US);
Markus Stoffel, New York, NY (US);
Assignees:
Alnylam Pharmaceuticals, Inc., Cambridge, MA (US);
Eth Zurich, Zurich, CH;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/02 (2006.01); C07H 21/04 (2006.01);
U.S. Cl.
CPC ...
Abstract
This invention relates to new compositions comprising at least one of a single or double stranded oligonucleotide, where said oligonucleotide has been conjugated to a lipophile and to which the conjugated oligonucleotide has been preassembled with lipoproteins. These compositions are effectively in delivering oligonucleotides to mammalian tissue where they effect gene silencing.