The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 04, 2012
Filed:
Aug. 09, 2010
Andreas Meinke, Pressbaum, AT;
Eszter Nagy, Vienna, AT;
Uwe Von Ahsen, Vienna, AT;
Christoph Klade, Wr. Neustadt, AT;
Tamas Henics, Vienna, AT;
Wolfgang Zauner, Vienna, AT;
Duc Bui Minh, Vienna, AT;
Oresta Vytvytska, Vienna, AT;
Hildegard Etz, Vienna, AT;
Agnieszka Dryla, Vienna, AT;
Thomas Weichhart, Böheimkirchen, AT;
Martin Hafner, Vienna, AT;
Brigitre Tempelmaier, Vienna, AT;
Claire M. Fraser, Potomac, MD (US);
Steven Gill, Frederick, MD (US);
Andreas Meinke, Pressbaum, AT;
Eszter Nagy, Vienna, AT;
Uwe Von Ahsen, Vienna, AT;
Christoph Klade, Wr. Neustadt, AT;
Tamas Henics, Vienna, AT;
Wolfgang Zauner, Vienna, AT;
Duc Bui Minh, Vienna, AT;
Oresta Vytvytska, Vienna, AT;
Hildegard Etz, Vienna, AT;
Agnieszka Dryla, Vienna, AT;
Thomas Weichhart, Böheimkirchen, AT;
Martin Hafner, Vienna, AT;
Brigitre Tempelmaier, Vienna, AT;
Claire M. Fraser, Potomac, MD (US);
Steven Gill, Frederick, MD (US);
Intercell AG, Vienna, AT;
Abstract
Described is a method for identification, isolation and production of hyperimmune serum-reactive antigens from a specific pathogen, a tumor, an allergen or a tissue or host prone to autoimmunity, said antigens being suited for use in a vaccine for a given type of animal or for humans, which is characterized by the following steps:—providing an antibody preparation from a plasma pool of said given type of animal or from a human plasma pool or individual sera with antibodies against said specific pathogen, tumor, allergen or tissue or host prone to auto-immunity,—providing at least one expression library of said specific pathogen, tumor, allergen or tissue or host prone to auto-immunity,—screening said at least one expression library with said antibody preparation,—identifying antigens which bind in said screening to antibodies in said antibody preparation,—screening the identified antigens with individual antibody preparations from individual sera from individuals with antibodies against said specific pathogen, tumor, allergen or tissue or host prone to auto-immunity,—identifying the hyperimmune serum-reactive antigen portion of said identified antigens and which hyperimmune serum-reactive antigens bind to a relevant portion of said individual antibody preparations from said individual sera and—optionally isolating said hyperimmune serum-reactive antigens and producing said hyperimmune serum-reactive antigens by chemical or recombinant methods.