The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 04, 2012
Filed:
May. 24, 2010
Manfred Schuster, Schrick, AT;
Gottfried Himmler, Vienna, AT;
Guenter Waxenecker, Mank, AT;
Geert C. Mudde, Breitenfurt, AT;
Manuela Loidl, Korneuburg, AT;
Gerda Redl, Rutzendorf, AT;
Hans Loibner, Vienna, AT;
Manfred Schuster, Schrick, AT;
Gottfried Himmler, Vienna, AT;
Guenter Waxenecker, Mank, AT;
Geert C. Mudde, Breitenfurt, AT;
Manuela Loidl, Korneuburg, AT;
Gerda Redl, Rutzendorf, AT;
Hans Loibner, Vienna, AT;
Meridian Biopharmaceuticals GmbH, Vienna, AT;
Greenovation Biotech GmbH, Freiburg, DE;
Abstract
The invention relates to a monoclonal antibody or derivative or fragment thereof that is derived from a parental monoclonal antibody, that recognizes the Lewis Y antigen, characterized in that the Fc region or region equivalent to the Fc region of said antibody or derivative or fragment thereof carries a bi-sected hybrid type N-glycosylation pattern and that said antibody shows at least 10 fold increased ADCC and at least 10% reduced CDC activity.