The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 27, 2012
Filed:
May. 14, 2008
Applicants:
Ulrich Weigl, Hilzingen, DE;
Pascal Schär, Bern, CH;
Alfred Stutz, Zürich, CH;
Inventors:
Assignee:
Cilag AG, Schaffhausen, CH;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 489/08 (2006.01); C07D 489/02 (2006.01);
U.S. Cl.
CPC ...
Abstract
Process for the preparation of N-methylnaltrexone bromide, wherein a compound of the general formula (I): whereinXrepresents an anion other than the bromide anion, and R represents hydrogen or a leaving group, is dissolved or dispersed in a suitable polar solvent, the solution or dispersion is mixed with a compound containing bromide anions, and the resulting reaction mixture is stirred until N-methylnaltrexone bromide has formed and crystallized, wherein, in the case where R represents a leaving group, that group is removed during or after the reaction.