The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 27, 2012
Filed:
Sep. 16, 2011
Michael Bech Jensen, Allerød, DK;
Anders Klarskov Petersen, Nærum, DK;
Andrew Neil Bowler, Gentofte, DK;
Michael Bech Jensen, Allerød, DK;
Anders Klarskov Petersen, Nærum, DK;
Andrew Neil Bowler, Gentofte, DK;
Novo Nordisk Health Care AG, Zurich, CH;
Abstract
The present invention is directed to liquid, aqueous pharmaceutical compositions stabilized against chemical and/or physical degradation containing Factor VII polypeptides, and methods for preparing and using such compositions, as well as vials containing such compositions, and the use of such compositions in the treatment of a Factor VII-responsive syndrome. The main embodiment is represented by a liquid, aqueous pharmaceutical composition comprising at least 0.01 mg/mL of a Factor VII polypeptide (i); a buffering agent (ii) suitable for keeping pH in the range of from about 4.0 to about 9.0; and at least one stabilizing agent (iii) comprising a —C(═N—Z—R)—NH—Z—Rmotif, e.g. benzamidine compounds and guanidine compounds such as arginine.