The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 27, 2012
Filed:
Aug. 10, 2009
Roger A. Rajewski, Lawrence, KS (US);
Mehmet Tanol, Lawrence, KS (US);
Ingrid Gunda Georg, St. Paul, MN (US);
Michelle P. Mcintosh, Warrandyte, AU;
Roger A. Rajewski, Lawrence, KS (US);
Mehmet Tanol, Lawrence, KS (US);
Ingrid Gunda Georg, St. Paul, MN (US);
Michelle P. McIntosh, Warrandyte, AU;
University of Kansas, Lawrence, KS (US);
Abstract
A prodrug that has a prodrug moiety that degrades into a compound having the general Formula I with R3 being an alcoholic moiety can be useful in therapies for neurodegenerative diseases as well as cancer. Accordingly, the prodrug compounds can have a structure of Formula I, analogs thereof, derivatives thereof, or salts thereof, wherein: A and B are sulfur or oxygen; R1 and R2, in para, meta, or ortho position, are independently halogen, alkyl, alkoxy, haloalkyl, where R1 and R2 independently are straight chain, branched, substituted or unsubstituted; and R3 is a prodrug moiety. As examples, the prodrug can have a structure of any of Formulas I-V, which as shown in the specification.