IDiyas

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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8318781 B1

PDFFull Text
Date of Patent:
Nov. 27, 2012

Filed:

Apr. 25, 2008

G-protein-conjugated receptor agonist

Applicants:

Gozoh Tsujimoto, Kyoto, JP;

Akira Hirasawa, Kyoto, JP;

Naoki Miyata, Nagoya, JP;

Takayoshi Suzuki, Nagoya, JP;

Yoshiyuki Takahara, Kyoto, JP;

Masaji Ishiguro, Takarazuka, JP;

Mie Hata, Kyoto, JP;

Inventors:

Gozoh Tsujimoto, Kyoto, JP;

Akira Hirasawa, Kyoto, JP;

Naoki Miyata, Nagoya, JP;

Takayoshi Suzuki, Nagoya, JP;

Yoshiyuki Takahara, Kyoto, JP;

Masaji Ishiguro, Takarazuka, JP;

Mie Hata, Kyoto, JP;

Assignees:

Japan Science and Technology Agency, Saitama, JP;

Kyoto University, Kyoto, JP;

Nagoya City University, Aichi, JP;

Attorney:

Licata & Tyrrell P.C.

Primary Examiner:

Jeffrey S Lundgren

Assistant Examiner:

William Lee

Int. Cl.
CPC ...
A01N 43/40 (2006.01); A01N 43/78 (2006.01); A01N 37/12 (2006.01); A01N 37/44 (2006.01); A01N 43/00 (2006.01); A61K 31/445 (2006.01); A61K 31/425 (2006.01); A61K 31/33 (2006.01); C07D 213/72 (2006.01); C07D 213/78 (2006.01); C07D 277/82 (2006.01); C07C 63/00 (2006.01); C07C 65/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

Disclosed is a novel aralkyl carboxylic acid compound which has an agonistic activity on GPR-120 and/or GPR-40, particularly GPR-120, and is therefore useful as an appetite regulator, an anti-obesity agent, a therapeutic agent for diabetes, a pancreatic beta differentiating cell growth enhancer, a therapeutic agent for metabolic syndrome, a therapeutic agent for a gastrointestinal disease, a therapeutic agent for a neuropathy, a therapeutic agent for a mental disorder, a therapeutic agent for a pulmonary disease, a therapeutic agent for a pituitary hormone secretion disorder or a lipid flavoring/seasoning agent. The aralkyl carboxylic acid compound is represented by the general formula (I). (I) wherein the ring Q represents a pyridyl or the like; Rrepresents a Calkyl group or the like; Rrepresents a hydrogen atom, a Calkyl group or a Calkoxy group; m and n independently represent an integer of 1 to 5; and X represents an oxygen atom, a sulfur atom or —NR— [wherein Rrepresents a hydrogen atom or a Calkyl group].

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