The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 27, 2012
Filed:
May. 13, 2005
Applicants:
Andrei Gudkov, Gates Mills, OH (US);
Michelle Haber, Coogee, AU;
Murray Norris, Surry Hills, AU;
Inventors:
Assignees:
The Cleveland Clinic Foundation, Cleveland, OH (US);
Children's Cancer Institute Australia for Medical Research, Randwick, New South Wales, AU;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/55 (2006.01);
U.S. Cl.
CPC ...
Abstract
A method of potentiating the activity of a therapeutic drug, like a chemotherapeutic drug or an antibiotic, in a cell or tissue, by inhibiting the efflux capability of a multidrug transporter are disclosed. The method is useful in the treatment of a cancer by sensitizing tumor cells to a chemotherapeutic agent. Compounds capable of inhibiting an efflux capability of a multidrug transporter also are disclosed.