The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 27, 2012

Filed:

Jan. 06, 2006
Applicants:

Jason Schense, Zurich, CH;

John Watson, Zumikon, CH;

Isabelle Arrighi, Zurich, CH;

Inventors:

Jason Schense, Zurich, CH;

John Watson, Zumikon, CH;

Isabelle Arrighi, Zurich, CH;

Assignee:

Kuros Biosurgery AG, Zurich, CH;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/29 (2006.01); A61K 38/00 (2006.01); C07K 14/635 (2006.01); A61P 19/08 (2006.01); A61P 19/10 (2006.01); A61P 5/18 (2006.01); C12N 15/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

A method of local treatment of specific bone defects such as osteoporosis or bone cysts comprises the step of local administration of a formulation comprising a fusion peptide containing a first domain comprising PTH or BMP 2 or BMP 7, and a second domain comprising a covalently crosslinkable substrate domain; and a material suitable of forming a biodegradable matrix suitable for cellular growth or in-growth, wherein the fusion peptide is covalently linked to the matrix. In one embodiment, the matrix contains one or more contrast agents, and is preferably formed in the absence of a growth factor. The matrix may be used in the treatment of fluid-filled cysts such as Tarlov cysts, ovarian cysts, arachnoid cysts, aneurysmal bone cysts or hepatic cysts.


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