The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 27, 2012
Filed:
Nov. 09, 2010
William W. Bachovchin, Cambridge, MA (US);
Andrew G. Plaut, Lexington, MA (US);
Daniel J. Drucker, Toronto, CA;
William W. Bachovchin, Cambridge, MA (US);
Andrew G. Plaut, Lexington, MA (US);
Daniel J. Drucker, Toronto, CA;
Trustees of Tufts College, Boston, MA (US);
New England Medical Center Hospitals, Inc., Boston, MA (US);
1149336 Ontario, Inc., Toronto, Ontario, CA;
Abstract
The present invention provides methods for modification and regulation of glucagon-like peptide 1 (GLP-1) metabolism by administering therapeutically effective amounts of an inhibitor of dipeptidylpeptidase IV (DPIV) or a pharmaceutically acceptable salt thereof, where the inhibitor has a Ki for inhibition of DPIV of 10 nM or less; and the inhibitor is administered in an amount sufficient to inhibit DPIV proteolysis of GLP-1 but not sufficient to suppress the immune system of the animal.