The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 27, 2012
Filed:
Jan. 14, 2009
Masahiro Iwamoto, Osaka, JP;
Yoshinobu Higuchi, Shizuoka, JP;
Maurizio Pacifici, Philadelphia, PA (US);
Joel Rosenbloom, Philadelphia, PA (US);
Masahiro Iwamoto, Osaka, JP;
Yoshinobu Higuchi, Shizuoka, JP;
Maurizio Pacifici, Philadelphia, PA (US);
Joel Rosenbloom, Philadelphia, PA (US);
University of Pennsylvania, Philadelphia, PA (US);
Abstract
This invention provides cell-calcification inhibitory proteins as well as genes encoding the proteins. Based on the discovery of a novel isoform gene of the c-erg gene (herein referred to as 'C-11 gene') which is an erg gene derived from chickens, the nucleotide sequence of the gene has been determined, and then the expression of a protein encoded by such gene (herein referred to as 'C-11 protein') has been confirmed. Further, it has been discovered that when the c-erg or C-11 gene is introduced into osteoblasts, the calcification of the cells is inhibited.