The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 27, 2012
Filed:
Oct. 06, 2008
Applicants:
Erich Koller, Carlsbad, CA (US);
C. Frank Bennett, Carlsbad, CA (US);
Inventors:
Erich Koller, Carlsbad, CA (US);
C. Frank Bennett, Carlsbad, CA (US);
Assignee:
Isis Pharmaceuticals, Inc., Carlsbad, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/00 (2006.01); C12Q 1/68 (2006.01); A01N 63/00 (2006.01); A01N 43/04 (2006.01); C07H 21/02 (2006.01); C07H 21/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention provides method of optimizing the efficacy and potency of antisense drugs. In certain embodiments, the invention provides assays useful for determining favorable oligonucleotide characteristics and excipeints for improved cellular uptake.