The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 27, 2012
Filed:
May. 19, 2005
Karel Domansky, Cambridge, MA (US);
Linda G. Griffith, Cambridge, MA (US);
Steven R. Tannenbaum, Framingham, MA (US);
Alan Wells, Pittsburgh, PA (US);
Samuel Walker Inman, Boston, MA (US);
Karel Domansky, Cambridge, MA (US);
Linda G. Griffith, Cambridge, MA (US);
Steven R. Tannenbaum, Framingham, MA (US);
Alan Wells, Pittsburgh, PA (US);
Samuel Walker Inman, Boston, MA (US);
Massachusetts Institute of Technology, Cambridge, MA (US);
Univeristy of Pittsburgh—Of the Commonwealth System of Higher Education, Pittsburgh, PA (US);
Abstract
A system has been constructed that recapitulate the features of a capillary bed through normal human tissue. The system facilitates perfusion of three-dimensional (3D) cell monocultures and heterotypic cell co-cultures at the length scale of the capillary bed. A major feature is that the system can be utilized within a 'multiwell plate' format amenable to high-throughput assays compatible with the type of robotics commonly used in pharmaceutical development. The system provides a means to conduct assays for toxicology and metabolism and as a model for human diseases such as hepatic diseases, including hepatitis, exposure-related pathologies, and cancer. Cancer applications include primary liver cancer as well as metastases. The system can also be used as a means of testing gene therapy approaches for treating disease and inborn genetic defects.