The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 27, 2012
Filed:
Feb. 17, 2009
Hartmuth C. Kolb, Playa Del Rey, CA (US);
Joseph C. Walsh, Pacific Palisades, CA (US);
Wei Zhang, Los Angeles, CA (US);
Peter J. H. Scott, Marina-del-Rey, CA (US);
Kai Chen, Los Angeles, CA (US);
Vani P. Mocharla, Los Angeles, CA (US);
Dhanalakshmi Kasi, Los Angeles, CA (US);
Gang Chen, Los Angeles, CA (US);
Eric Wang, San Diego, CA (US);
Anjana Sinha, San Diego, CA (US);
Hartmuth C. Kolb, Playa Del Rey, CA (US);
Joseph C. Walsh, Pacific Palisades, CA (US);
Wei Zhang, Los Angeles, CA (US);
Peter J. H. Scott, Marina-del-Rey, CA (US);
Kai Chen, Los Angeles, CA (US);
Vani P. Mocharla, Los Angeles, CA (US);
Dhanalakshmi Kasi, Los Angeles, CA (US);
Gang Chen, Los Angeles, CA (US);
Eric Wang, San Diego, CA (US);
Anjana Sinha, San Diego, CA (US);
Siemens Medical Solutions USA, Inc., Malvern, PA (US);
Abstract
Disclosed here in are compounds and methods of diagnosing Alzheimer's Disease or a predisposition thereto in a mammal, the method comprising administering to the mammal a diagnostically effective amount of a radiolabeled compound, wherein the compound is selected from the group consisting of radiolabeled flavones, coumarins, carbazoles, quinolinones, chromenones, imidazoles and triazoles derivatives, allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing Alzheimer's Disease.