The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 20, 2012
Filed:
Aug. 06, 2008
Sanjay Kumar, Mumbai, IN;
Kalpana Sanjay Joshi, Mumbai, IN;
Vijaykumar Deore, Mumbai, IN;
Mandar Ramesh Bhonde, Pune, IN;
Nilambari Nilkanth Yewalkar, Mumbai, IN;
Amol Arun Padgaonkar, Mumbai, IN;
Asha Adrian Kulkarni-almeida, Mumbai, IN;
Maggie Joyce Rathos, Mumbai, IN;
Sapna Parikh, Mumbai, IN;
Nilesh Madhukar Dagia, Mumbai, IN;
Sanjay Kumar, Mumbai, IN;
Kalpana Sanjay Joshi, Mumbai, IN;
Vijaykumar Deore, Mumbai, IN;
Mandar Ramesh Bhonde, Pune, IN;
Nilambari Nilkanth Yewalkar, Mumbai, IN;
Amol Arun Padgaonkar, Mumbai, IN;
Asha Adrian Kulkarni-Almeida, Mumbai, IN;
Maggie Joyce Rathos, Mumbai, IN;
Sapna Parikh, Mumbai, IN;
Nilesh Madhukar Dagia, Mumbai, IN;
Piramal Enterprises Limited, Mumbai, Maharashtra, IN;
Abstract
The present invention relates to pyridyl derivatives capable of inhibiting phosphatidylinositol-3-kinase (PI3k), mammalian target of rapamycin (mTOR) and/or hypoxia inducible factor 1α (HIF-1α) mediated signaling. Also disclosed are processes for preparation of the pyridyl derivatives, and their use in the manufacture of pharmaceutical compositions for the treatment of clinical conditions caused by deregulation of signaling pathways selected from one or more of PI3K, mTOR and HIF-1α pathways. The pyridyl derivatives are also useful for the treatment of conditions or disorders mediated by TNF-α.