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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8314097 B1

PDFFull Text
Date of Patent:
Nov. 20, 2012

Filed:

Aug. 23, 2006

Organic compounds

Applicants:

Gary Michael Ksander, Amherst, NH (US);

Erik Meredith, Hudson, MA (US);

Lauren G. Monovich, Belmont, MA (US);

Julien Papillon, Somerville, MA (US);

Fariborz Firooznia, Florham Park, NJ (US);

Qi-ying HU, Needham, MA (US);

Inventors:

Gary Michael Ksander, Amherst, NH (US);

Erik Meredith, Hudson, MA (US);

Lauren G. Monovich, Belmont, MA (US);

Julien Papillon, Somerville, MA (US);

Fariborz Firooznia, Florham Park, NJ (US);

Qi-Ying Hu, Needham, MA (US);

Assignee:

Novartis AG, Basel, CH;

Attorneys:

Stephen Johnson

Joseph T. Majka

Primary Examiner:

Brenda Coleman

Int. Cl.
CPC ...
A61K 31/535 (2006.01); A61K 31/445 (2006.01); A61K 31/415 (2006.01); A61P 9/00 (2006.01); C07D 413/00 (2006.01); C07D 211/32 (2006.01); C07D 235/02 (2006.01); C07D 487/10 (2006.01); C07D 403/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention provides a compound of formula I: Said compound is inhibitor of aldosterone synthase and aromatase, and thus can be employed for the treatment of a disorder or disease mediated by aldosterone synthase or aromatase. Accordingly, the compound of formula I can be used in treatment of hypokalemia, hypertension, congestive heart failure, atrial fibrillation, renal failure, in particular, chronic renal failure, restenosis, atherosclerosis, syndrome X, obesity, nephropathy, post-myocardial infarction, coronary heart diseases, inflammation, increased formation of collagen, fibrosis such as cardiac or myocardiac fibrosis and remodeling following hypertension and endothelial dysfunction, gynecomastia, osteoporosis, prostate cancer, endometriosis, uterine fibroids, dysfunctional uterine bleeding, endometrial hyperplasia, polycystic ovarian disease, infertility, fibrocystic breast disease, breast cancer and fibrocystic mastopathy. Finally, the present invention also provides a pharmaceutical composition.

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Ksander, Gary. (2012). Organic compounds (U.S. Patent No. 8314097). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/8314097

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