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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8314091 B1

PDFFull Text
Date of Patent:
Nov. 20, 2012

Filed:

Aug. 19, 2008

N-benzyl,n'-arylcarbonylpiperazine derivatives

Applicants:

Koc-kan Ho, West Windsor, NJ (US);

Andrew Laird Roughton, Plainsboro, NJ (US);

Irina Neagu, Plainsboro, NJ (US);

Jui-hsiang Chan, West Windsor, NJ (US);

Nasrin Ansari, Monmouth Junction, NJ (US);

Michelle Lee Morris, Lawrenceville, NJ (US);

Yajing Rong, Dayton, NJ (US);

Michael Ohlmeyer, Plainsboro, NJ (US);

Andrew John Cooke, Newhouse, GB;

Andrew Stanley Edwards, Newhouse, GB;

David Jonathan Bennett, Newhouse, GB;

Inventors:

Koc-Kan Ho, West Windsor, NJ (US);

Andrew Laird Roughton, Plainsboro, NJ (US);

Irina Neagu, Plainsboro, NJ (US);

Jui-Hsiang Chan, West Windsor, NJ (US);

Nasrin Ansari, Monmouth Junction, NJ (US);

Michelle Lee Morris, Lawrenceville, NJ (US);

Yajing Rong, Dayton, NJ (US);

Michael Ohlmeyer, Plainsboro, NJ (US);

Andrew John Cooke, Newhouse, GB;

Andrew Stanley Edwards, Newhouse, GB;

David Jonathan Bennett, Newhouse, GB;

Assignees:

MSD OSS B.V., Oss, NL;

Pharmacopeia, Inc., Cranbury, NJ (US);

Attorneys:

James L. McGinnis

Catherine D. Fitch

Susan Hess

Primary Examiner:

Sreeni Padmanabhan

Assistant Examiner:

Sarah Pihonak

Int. Cl.
CPC ...
A01N 43/62 (2006.01); A01N 43/58 (2006.01); A01N 43/60 (2006.01); A61K 31/55 (2006.01); A61K 31/535 (2006.01); A61K 31/50 (2006.01); A61K 31/495 (2006.01); A61K 31/497 (2006.01); A61K 31/4965 (2006.01); C07D 243/00 (2006.01); C07D 487/22 (2006.01); C07D 491/00 (2006.01); C07D 498/00 (2006.01); C07D 243/08 (2006.01); C07D 413/00 (2006.01); C07D 239/02 (2006.01); C07D 241/36 (2006.01); C07D 271/00 (2006.01); C07D 487/00 (2006.01); C07D 495/00 (2006.01); C07D 497/00 (2006.01); C07D 513/00 (2006.01); C07D 417/00 (2006.01); C07D 419/00 (2006.01); C07D 241/02 (2006.01); C07D 403/00 (2006.01); C07D 411/00 (2006.01); C07D 295/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention relates to N-benzyl,N'-arylcarbonylpiperazine derivatives having the general formula I to pharmaceutical compositions comprising the same, and to the use of a these N-benzyl,N′-arylcarbonylpiperazine derivatives for the manufacture of a medicament for treating or preventing atherosclerosis and related disorders associated with cholesterol and bile acids transport and metabolism.

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