The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 20, 2012
Filed:
Nov. 06, 2009
J. Jeffry Howbert, Bellevue, WA (US);
Venkat Reddy Kusukuntla, Germantown, WI (US);
Alexander Tretyakov, Grafton, WI (US);
Nathan Nielsen, Toronto, CA;
Pavel Krasik, Aurora, CA;
Ji-long Jiang, Toronto, CA;
Hong Woon Yang, Superior, CO (US);
J. Jeffry Howbert, Bellevue, WA (US);
Venkat Reddy Kusukuntla, Germantown, WI (US);
Alexander Tretyakov, Grafton, WI (US);
Nathan Nielsen, Toronto, CA;
Pavel Krasik, Aurora, CA;
Ji-Long Jiang, Toronto, CA;
Hong Woon Yang, Superior, CO (US);
VentiRx Pharmaceuticals, Inc., Seattle, WA (US);
Array BioPharma, Inc., Boulder, CO (US);
Abstract
The disclosure describes method of synthesis of substituted benzazepine derivatives. Preferred methods according to the disclosure allow for large-scale preparation of benzazepine compounds having low levels of metal impurities. In some embodiments, preferred methods according to the disclosure also allow for the preparation of benzazepine derivatives without the use of chromatographic purification methods and in better yield than previously used methods for preparing such compounds. The methods disclosed herein find utility in synthetic organic chemistry as well as medicinal chemistry.