The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 20, 2012
Filed:
Sep. 17, 2010
Michael James Moser, Madison, WI (US);
David J. Marshall, Madison, WI (US);
James R. Prudent, Madison, WI (US);
Cristopher V. Van Hout, Ann Arbor, MI (US);
Christine A. Larsen, Corvallis, OR (US);
Michael James Moser, Madison, WI (US);
David J. Marshall, Madison, WI (US);
James R. Prudent, Madison, WI (US);
Cristopher V. Van Hout, Ann Arbor, MI (US);
Christine A. Larsen, Corvallis, OR (US);
Luminex Corporation, Austin, TX (US);
Abstract
The present invention provides nucleic acid based polymerase inhibitors and methods for reducing non-specific polymerase extension and amplification in nucleic acid amplification reactions. The polymerase inhibitors provide a double stranded nucleic acid portion that is recognized by a polymerase enzyme as a template for extension but is incapable of being extended by the polymerase enzyme. The polymerase binds to the polymerase inhibitor which sequesters the enzyme until the temperature achieves a level that denatures the double stranded portion of the inhibitor after which the polymerase is released and can then catalyze nucleic acid extension.