The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 13, 2012
Filed:
Nov. 29, 2011
Ching-shih Chen, Upper Arlington, OH (US);
Samuel K. Kulp, Hillard, OH (US);
Dasheng Wang, Dublin, OH (US);
John C. Byrd, Columbus, OH (US);
Natarajan Muthusamy, Galloway, OH (US);
Ching-Shih Chen, Upper Arlington, OH (US);
Samuel K. Kulp, Hillard, OH (US);
Dasheng Wang, Dublin, OH (US);
John C. Byrd, Columbus, OH (US);
Natarajan Muthusamy, Galloway, OH (US);
The Ohio State University Research Foundation, Columbus, OH (US);
Abstract
A number of FTY720-derived compounds with antitumor activity are described. These compounds include the compounds of formula I: wherein Ris independently selected from the group consisting of hydrogen, methyl. methoxy, and hydroxyl; Ris independently selected from the group consisting of hydrogen, methoxy, and hydroxyl; Ris independently selected from the group consisting of alkyl and cyclo-alkyl; and n is independently selected from 0 to 6. The compounds have lower immunosuppressive side effects as a result of not being phosphorylated by sphingosine kinase 2.