The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 13, 2012
Filed:
Mar. 29, 2010
Applicants:
Phillip D. Zamore, Northboro, MA (US);
Gyorgy Hutvagner, Worcester, MA (US);
Dianne Schwarz, Westborough, MA (US);
Martin Simard, Deschambault, CA;
Inventors:
Phillip D. Zamore, Northboro, MA (US);
Gyorgy Hutvagner, Worcester, MA (US);
Dianne Schwarz, Westborough, MA (US);
Martin Simard, Deschambault, CA;
Assignee:
University of Massachusetts, Boston, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/00 (2006.01); C07H 21/02 (2006.01); C07H 21/04 (2006.01); C12P 19/34 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention provides methods of enhancing the efficacy and specificity of RNA silencing. The invention also provides compositions for mediating RNA silencing. In particular, the invention provides siRNAs, siRNA-like molecules, shRNAs, vectors and transgenes having improved specificity and efficacy in mediating silencing of a target gene. Therapeutic methods are also featured.