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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8309549 B1

PDFFull Text
Date of Patent:
Nov. 13, 2012

Filed:

Apr. 26, 2011

Compositions for modulating a kinase cascade and methods of use thereof

Applicants:

David G. Hangauer, Jr., Lancaster, NY (US);

Debasis Patra, Manlius, NY (US);

Jeremy A. Cody, Clifton Springs, NY (US);

Grant J. Palmer, Nashville, TN (US);

Paul K. Isbester, Castleton on Hudson, NY (US);

Jonathon Salsbury, Madison, WI (US);

Inventors:

David G. Hangauer, Jr., Lancaster, NY (US);

Debasis Patra, Manlius, NY (US);

Jeremy A. Cody, Clifton Springs, NY (US);

Grant J. Palmer, Nashville, TN (US);

Paul K. Isbester, Castleton on Hudson, NY (US);

Jonathon Salsbury, Madison, WI (US);

Assignee:

Kinex Pharmaceuticals, LLC, Buffalo, NY (US);

Attorneys:

Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.

Ivor R. Elrifi

Heidi A. Erlacher

Primary Examiner:

Raymond Henley, Iii

Int. Cl.
CPC ...
A61K 31/5377 (2006.01); C07D 413/12 (2006.01);
U.S. Cl.
CPC ...
Abstract

The invention relates to compositions comprising 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts. The invention provides an efficient process for the synthesis of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts and methods for modulating one or more components of a kinase cascade using the compositions of the invention. The present invention also provides a novel polymorph of the mesylate salt of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide (Form A), characterized by a unique X-ray diffraction pattern and Differential Scanning Calorimetry profile, as well as a unique crystalline structure.

Find Patent Forward Citations

Hangauer, Jr., David. (2012). Compositions for modulating a kinase cascade and methods of use thereof (U.S. Patent No. 8309549). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/8309549

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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