The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 13, 2012
Filed:
Apr. 26, 2011
David G. Hangauer, Jr., Lancaster, NY (US);
Debasis Patra, Manlius, NY (US);
Jeremy A. Cody, Clifton Springs, NY (US);
Grant J. Palmer, Nashville, TN (US);
Paul K. Isbester, Castleton on Hudson, NY (US);
Jonathon Salsbury, Madison, WI (US);
David G. Hangauer, Jr., Lancaster, NY (US);
Debasis Patra, Manlius, NY (US);
Jeremy A. Cody, Clifton Springs, NY (US);
Grant J. Palmer, Nashville, TN (US);
Paul K. Isbester, Castleton on Hudson, NY (US);
Jonathon Salsbury, Madison, WI (US);
Kinex Pharmaceuticals, LLC, Buffalo, NY (US);
Abstract
The invention relates to compositions comprising 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts. The invention provides an efficient process for the synthesis of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts and methods for modulating one or more components of a kinase cascade using the compositions of the invention. The present invention also provides a novel polymorph of the mesylate salt of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide (Form A), characterized by a unique X-ray diffraction pattern and Differential Scanning Calorimetry profile, as well as a unique crystalline structure.