The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 13, 2012
Filed:
Jul. 28, 2010
Jason C. Schense, Zurich, CH;
Hugo Schmoekel, Zurich, CH;
Jeffrey A. Hubbell, Epalinges, CH;
Franz Weber, Zurich, CH;
Jason C. Schense, Zurich, CH;
Hugo Schmoekel, Zurich, CH;
Jeffrey A. Hubbell, Epalinges, CH;
Franz Weber, Zurich, CH;
Eidgenossische Technische Hochschule Zurich, Zurich, CH;
Universitat Zurich, Zurich, CH;
Abstract
Bioactive molecules are entrapped within a matrix for the controlled delivery of these compounds for therapeutic healing applications. The matrix may be formed of natural or synthetic compounds. The primary method of entrapment of the bioactive molecule is through precipitation of the bioactive molecule during gelation of the matrix, either in vitro or in vivo. The bioactive molecule may be modified to reduce its effective solubility in the matrix to retain it more effectively within the matrix, such as through the deglycosylation of members within the cystine knot growth factor superfamily and particularly within the TGFβ superfamily. The matrix may be modified to include sites with binding affinity for different bioactive molecules, for example, for heparin binding.