The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 13, 2012
Filed:
May. 30, 2008
Applicants:
Shoen Kume, Kumamoto, JP;
Nobuaki Shiraki, Kumamoto, JP;
Kahoko Umeda, Kumamoto, JP;
Kazuhiko Kume, Kumamoto, JP;
Inventors:
Shoen Kume, Kumamoto, JP;
Nobuaki Shiraki, Kumamoto, JP;
Kahoko Umeda, Kumamoto, JP;
Kazuhiko Kume, Kumamoto, JP;
Assignee:
Kumamoto University, Kumamoto, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/00 (2006.01); C12N 5/02 (2006.01); C12N 5/07 (2010.01); C12N 5/10 (2006.01); C12N 5/071 (2010.01);
U.S. Cl.
CPC ...
Abstract
It is an object of the present invention to establish a system for reliably differentiating an ES cell into a hepatic cell. The present invention provides a method for inducing the differentiation of an ES cell into a hepatic cell, which comprises, in the presence of an M15 cell, culturing a mammal-derived ES cell in the presence of activin and bFGF, and then culturing the ES cell in the presence of dexamethasone, HGF, and oncostatin M.