The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 13, 2012
Filed:
Dec. 07, 2009
Zheng Zhang, Cambridge, MA (US);
Chad Huval, Somerville, MA (US);
William Shannan O'shaughnessey, Boston, MA (US);
Michael Hencke, Cambridge, MA (US);
Trevor Squier, Peabody, MA (US);
Jun LI, Brookline, MA (US);
Michael Bouchard, Wyomissing, PA (US);
Christopher R. Loose, Cambridge, MA (US);
Zheng Zhang, Cambridge, MA (US);
Chad Huval, Somerville, MA (US);
William Shannan O'Shaughnessey, Boston, MA (US);
Michael Hencke, Cambridge, MA (US);
Trevor Squier, Peabody, MA (US);
Jun Li, Brookline, MA (US);
Michael Bouchard, Wyomissing, PA (US);
Christopher R. Loose, Cambridge, MA (US);
Semprus Biosciences Corp., Cambridge, MA (US);
Abstract
Substrates, optionally coated with an undercoating, having grafted thereto one or more non-fouling materials are described herein. The non-fouling, polymeric material can be grafted to a variety of functionalized substrate materials, particularly polymeric substrates and/or polymeric undercoatings immobilized on a substrate. The compositions described herein are highly resistant protein absorption, particularly in complex media and retain a high degree of non-fouling activity over long periods of time. The compositions described herein may also demonstrate antimicrobial and/or anti-thrombogenic activity. The non-fouling material can be grafted to a functionalized substrate, or optionally from an undercoating on the substrate, preferably without significantly affecting the mechanical and/or physical properties of the substrate material.