The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 06, 2012
Filed:
Dec. 02, 2008
Joern Merten, Gau Algesheim, DE;
Guenter Linz, Mittelbiberach, DE;
Juergen Schnaubelt, Warthausen, DE;
Rolf Schmid, Baltringen, DE;
Werner Rall, Mittelbiberach, DE;
Svenja Renner, Eckenroth, DE;
Carsten Reichel, Rheinboellen, DE;
Robert Schiffers, Gau Algesheim, DE;
Joern Merten, Gau Algesheim, DE;
Guenter Linz, Mittelbiberach, DE;
Juergen Schnaubelt, Warthausen, DE;
Rolf Schmid, Baltringen, DE;
Werner Rall, Mittelbiberach, DE;
Svenja Renner, Eckenroth, DE;
Carsten Reichel, Rheinboellen, DE;
Robert Schiffers, Gau Algesheim, DE;
Boehringer Ingelheim International GmbH, Ingelheim am Rhein, DE;
Abstract
The present invention relates to a process for the manufacture of a specific indolinone derivative and a pharmaceutically acceptable salt thereof, namely 3-Z-[1-(4-(N-((4-methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone and its monoethanesulfonate, to new manufacturing steps and to new intermediates of this process.