The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 06, 2012
Filed:
Jun. 03, 2009
Karl Kossen, Brisbane, CA (US);
Scott D. Seiwert, Pacifica, CA (US);
Vladimir Serebryany, Burlingame, CA (US);
Donald Ruhrmund, San Francisco, CA (US);
Leonid Beigelman, San Mateo, CA (US);
Luca Francesco Mario Raveglia, Milan, IT;
Stefania Vallese, Cardano al Campo, IT;
Ivana Bianchi, Fagnano Olona, IT;
Tao HU, Shanghai, CN;
Karl Kossen, Brisbane, CA (US);
Scott D. Seiwert, Pacifica, CA (US);
Vladimir Serebryany, Burlingame, CA (US);
Donald Ruhrmund, San Francisco, CA (US);
Leonid Beigelman, San Mateo, CA (US);
Luca Francesco Mario Raveglia, Milan, IT;
Stefania Vallese, Cardano al Campo, IT;
Ivana Bianchi, Fagnano Olona, IT;
Tao Hu, Shanghai, CN;
Intermune, Inc., Brisbane, CA (US);
Abstract
Disclosed are compounds and methods for treating inflammatory and fibrotic disorders, including methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of the p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the p38 MAPK by the compound. Also disclosed are derivatives and analogs of pirfenidone, useful for modulating a stress activated protein kinase (SAPK) system.