The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 06, 2012
Filed:
Mar. 08, 2007
Christopher J. Ackerson, Raleigh, NC (US);
Pablo Jadzinsky, Stanford, CA (US);
Roger D. Kornberg, Atherton, CA (US);
Christopher J. Ackerson, Raleigh, NC (US);
Pablo Jadzinsky, Stanford, CA (US);
Roger D. Kornberg, Atherton, CA (US);
The Board of Trustees of the Leland Stanford Junior University, Palo Alto, CA (US);
Abstract
Improved methods for preparing thiolate passivated gold nanoparticles are provided resulting in a narrower size distribution. By alternating oxidation and reduction of the particles, after oxidation, the thiolates may be readily displaced with a different thiol, followed by reduction to prevent further reaction. Proteins can be rigidly bound to the gold nanoparticles by binding an scFv for a target protein to the gold nanoparticles, where the scFv prior or subsequent to binding to the gold nanoparticles may be complexed with the target protein. The protein is rigidly held and its structure readily determined using electron microscopy.