The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 06, 2012
Filed:
Dec. 01, 2006
Jesse Smith, Watham, MA (US);
Jill Milne, Brookline, MA (US);
Amy Lynch, Boston, MA (US);
David Carney, Derry, NH (US);
Andre Iffland, Cambridge, MA (US);
Olivier Boss, Boston, MA (US);
Jesse Smith, Watham, MA (US);
Jill Milne, Brookline, MA (US);
Amy Lynch, Boston, MA (US);
David Carney, Derry, NH (US);
Andre Iffland, Cambridge, MA (US);
Olivier Boss, Boston, MA (US);
Sirtris Pharmaceuticals, Inc., Cambridge, MA (US);
Abstract
Provided are methods for determining the activity of proteins that modulate the acetylation state of a protein substrate. The methods may be used for determining both acetyltransferase activity and deacetylase activity. The methods utilize mass spectrometry for determining the acetylation state of a substrate peptide. The methods may also be used to identify compounds that modulate the activity of a protein having acetyltransferase or deacetylase activity. In some embodiments, a compound that modulates a deacetylase is an activator of the deacetylase.