The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 06, 2012
Filed:
Sep. 29, 2009
Andreas Kappel, Königstein, DE;
Andrea Lichte, Marburg, DE;
Norbert Zander, Marburg, DE;
Stefan Teigelkamp, Niederwalgern, DE;
Sabine Teigelkamp, Legal Representative, Niederwalgern, DE;
Carsten Schelp, Hockessin, DE;
Andreas Kappel, Königstein, DE;
Andrea Lichte, Marburg, DE;
Norbert Zander, Marburg, DE;
Stefan Teigelkamp, Niederwalgern, DE;
Sabine Teigelkamp, legal representative, Niederwalgern, DE;
Carsten Schelp, Hockessin, DE;
Abstract
The invention relates to methods for determining the activity of a proteolytic coagulation factor of the blood coagulation cascade in a body fluid such as whole blood or plasma. A combination is provided in a reaction mixture. The combination comprises the sample and an activation agent for activating a proteolytic coagulation factor of the blood coagulation cascade or for activating the blood coagulation cascade. The effect of the activating on a reagent system comprising a cleavable moiety is evaluated. The cleavable moiety is or becomes bound to a chemiluminescent agent or a sensitizer agent or both. The chemiluminescent agent and the sensitizer agent are related in that, when in close proximity, energization of the sensitizer agent results in energization of the chemiluminescent agent. The effect of the activating is related to the activity of a proteolytic coagulation factor of the blood coagulation cascade wherein the effect is the extent of cleavage of the cleavable moiety.