The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 06, 2012
Filed:
Dec. 05, 2008
Hüseyin Firat, Paris, FR;
Pierre Langlade-demoyan, Paris, FR;
Etienne Vilmer, Paris, FR;
François Lemonnier, Bourg la Reine, FR;
Pierre Rohrlich, Saint Mande, FR;
Patricia Yotnda, Houston, TX (US);
Hüseyin Firat, Paris, FR;
Pierre Langlade-Demoyan, Paris, FR;
Etienne Vilmer, Paris, FR;
François Lemonnier, Bourg la Reine, FR;
Pierre Rohrlich, Saint Mande, FR;
Patricia Yotnda, Houston, TX (US);
Institut Pasteur, Paris, FR;
Abstract
The invention concerns the optimization of the wild R9M peptide and the use of the resulting peptides for therapeutic vaccination and/or preventive vaccination against leukaemia in humans. More particularly, the invention concerns mutated immunogenic peptides derived from the human TEL/AML1 fusion protein comprising the wild R9M peptide sequence Arg-Ile-Ala-Glu-Czs-Ile-Leu-Gly-Met. The invention also concerns polynucleotides coding for the mutated R9M immunogenic peptides, cellular expression vectors comprising nucleic acid sequences expressing the mutated R9M immunogenic peptides and polyclonal or monoclonal antibodies capable of being fixed on at least one of said peptides/polynucleotides. The invention further concerns the use of said peptides, polynucleotides and/or antibodies for preparing vaccines, anti-tumoral medicines and compositions and for in vitro and in vivo stimulation of the immune response in humans.