The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 06, 2012
Filed:
May. 01, 2008
Eva Maria Dahlén, Arlöv, SE;
Karin Elisabeth Barchan, Kalgshamn, SE;
Patrick Thomas Höjman, Malmö, SE;
Cecilia Ann-christin Malmborg Hager, Helsingborg, SE;
Marie Asa Ingegerd Karlsson, Lund, SE;
Mats Peter Anderson, Kävlinge, SE;
Björn Ulrik Walse, Lund, SE;
Eva Maria Dahlén, Arlöv, SE;
Karin Elisabeth Barchan, Kalgshamn, SE;
Patrick Thomas Höjman, Malmö, SE;
Cecilia Ann-Christin Malmborg Hager, Helsingborg, SE;
Marie Asa Ingegerd Karlsson, Lund, SE;
Mats Peter Anderson, Kävlinge, SE;
Björn Ulrik Walse, Lund, SE;
Alligator Bioscience AB, Lund, SE;
Abstract
The invention provides an isolated polypeptide comprising a variant amino acid sequence of SEQ ID NO: 1, or a fusion or derivative of said polypeptide, or a fusion of a said derivative thereof, wherein the polypeptide, fusion or derivative retains a biological activity of wild type IL-IRa. In one embodiment, the isolated polypeptide, fusion or derivative is or comprises a polypeptide variant of amino acid sequence SEQ ID NO: 1 comprising or consisting of substitutions at one or more of the following amino acid mutations of SEQ ID NO: 1: Q29K, P38Y, P38R, L42W, D47N, E52R, H54R, E90Y, Q129L, Q129N, M136N, M136D and Q149K. Also provided are pharmaceutical compositions of the above polypeptide, fusion or derivative, as well as uses of the same for treating a disease or condition capable of being treated by an agent which inhibits the function of IL-1 receptors.