The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 30, 2012
Filed:
Nov. 04, 2009
Applicants:
Greg S. Buenger, Charles City, IA (US);
Paul A. Jass, Charles City, IA (US);
Kezia Peixoto Schutz, Charles City, IA (US);
Inventors:
Greg S. Buenger, Charles City, IA (US);
Paul A. Jass, Charles City, IA (US);
Kezia Peixoto Schutz, Charles City, IA (US);
Assignee:
Cambrex Charles City, Charles City, IA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 401/00 (2006.01); C07D 405/00 (2006.01); C07D 409/00 (2006.01); C07D 411/00 (2006.01); C07D 413/00 (2006.01); C07D 417/00 (2006.01); C07D 419/00 (2006.01); C07D 421/00 (2006.01); C07D 211/56 (2006.01); C07D 211/92 (2006.01); A61K 31/445 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention relates to a process for the preparation of piperidine derivatives including sufentanil, and their pharmaceutically acceptable salts, such as the citrate salt in which a quaternary ammonium (nosylate) salt of an appropriate piperidine is reacted with a corresponding 4-NOsulfonate ester to produce the desired piperidine derivative at a high purity.