The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 30, 2012
Filed:
Nov. 15, 2007
Adrian Walmsley, Well am Rheim, DE;
William Leonard Wishart, Allschwil, CH;
Marta Cortes-cros, Basel, CH;
Josef Prassler, Germering, DE;
Ingo Klagge, Neuried, DE;
Adrian Walmsley, Well am Rheim, DE;
William Leonard Wishart, Allschwil, CH;
Marta Cortes-Cros, Basel, CH;
Josef Prassler, Germering, DE;
Ingo Klagge, Neuried, DE;
Novartis AG, Basel, CH;
Abstract
The present invention provides a binding molecule which is capable of binding to the rat, cynomolgus monkey and human LINGO polypeptide, and a polynucleotide encoding the binding molecule. The invention also provides an expression vector comprising the polynucleotide, an expression system comprising a polynucleotide capable of producing a binding molecule, as well as an isolated host cell comprising the expression system for producing the binding molecule. The invention also provides for compositions comprising the LINGO binding molecules and the use of binding molecule compositions as a pharmaceutical, especially in the treatment to promote axonal regeneration/plasticity. The invention further provides for a method of treatment of diseases associated with axonal degeneration and demyelination.