The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 30, 2012
Filed:
Oct. 05, 2007
Kapil Mehta, Bellaire, TX (US);
Amit Verma, Haryana, IN;
Sushovan Guha, Missouri City, TX (US);
Jansina Fok, Houston, TX (US);
Gabriel Lopez-berestein, Bellaire, TX (US);
Anil Sood, Pearland, TX (US);
Kapil Mehta, Bellaire, TX (US);
Amit Verma, Haryana, IN;
Sushovan Guha, Missouri City, TX (US);
Jansina Fok, Houston, TX (US);
Gabriel Lopez-Berestein, Bellaire, TX (US);
Anil Sood, Pearland, TX (US);
Board of Regents, The University of Texas System, Austin, TX (US);
Abstract
A method for treating cancer comprising inhibiting transglutaminase activity is provided. Suitable cancer types for which the methods of the present disclosure can be used to treat include, but are not limited to, pancreatic, breast, and ovarian cancers and melanoma. The inhibition of transglutaminase activity may be performed by one or more techniques, including, but not limited to, downregulating transglutaminase expression, inhibiting TG2 translation, or blocking TG2 enzymatic activity, such as with a small molecule inhibitor or intracellular antibody (intrabody).