The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 30, 2012
Filed:
Sep. 17, 2010
Perry Francis Bartlett, Carlton North, AU;
Elizabeth Jane Coulson, Clifton Hill, AU;
Katrina Fieldew, Box Hill North, AU;
Manuel Baca, Ivanhoe, AU;
Trevor Kilpatrick, Parkville, AU;
Cheema Surindar, Donvale, AU;
Perry Francis Bartlett, Carlton North, AU;
Elizabeth Jane Coulson, Clifton Hill, AU;
Katrina Fieldew, Box Hill North, AU;
Manuel Baca, Ivanhoe, AU;
Trevor Kilpatrick, Parkville, AU;
Cheema Surindar, Donvale, AU;
The University of Queensland, Queensland, AU;
Abstract
The present invention relates generally to a method for modulating cell survival. Modulation of cell survival includes inducing, enhancing or otherwise promoting cell survival such as the survival of neural cells as well as facilitating cell death such as the death of targeted cancer cells. The modulation of cell survival is mediated by a region identified on the p75 neurotrophin receptor (p75) required for death signalling. The present invention further provides genetic molecules which encode the death signalling region of p75which are useful in antagonising death signal function as well as promoting cell death when expressed in targeted cells. The present invention also contemplates recombinant peptides, polypeptides and proteins as well as chemical equivalents, derivatives and homologues thereof which comprise the death signalling portion of p75. Particularly useful molecules of the present invention comprise peptides corresponding to soluble forms of the death signalling portion of p75. These molecules antagonise p75-mediated cell death.