The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 30, 2012
Filed:
Dec. 12, 2008
Shunji Tomatsu, Clayton, MO (US);
Ken'ichi Miyamoto, Ishikawa, JP;
Masamichi Yamada, Hyogo, JP;
Yasuhiro Tosaka, Hyogo, JP;
Mana Yamada, Hyogo, JP;
Shunji Tomatsu, Clayton, MO (US);
Ken'ichi Miyamoto, Ishikawa, JP;
Masamichi Yamada, Hyogo, JP;
Yasuhiro Tosaka, Hyogo, JP;
Mana Yamada, Hyogo, JP;
Saint Louis University, St. Louis, MO (US);
Kanazawa University, Kanazawa, Ishikawa, JP;
JCR Pharmaceuticals Co., Ltd., Ashiya, JP;
Abstract
Disclosed are a fusion protein comprising enzyme N-acetylgalactosamine-6-sulfate sulfatase and a short peptide consisting of 4-15 acidic amino acids attached to the enzyme on its N-terminal side, a pharmaceutical composition containing the fusion protein, and a method for treatment of type A Morquio disease using the fusion protein. Compared with the native enzyme protein, the fusion protein exhibits higher transferability to bone tissues and improved, higher stability in the blood.