The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 16, 2012

Filed:

Aug. 18, 2008
Applicants:

Donatella Chianelli, San Diego, CA (US);

Valentina Molteni, San Diego, CA (US);

Xiaolin LI, San Diego, CA (US);

Xiaodong Liu, San Diego, CA (US);

Juliet Nabakka, San Diego, CA (US);

Jon Loren, San Diego, CA (US);

Inventors:

Donatella Chianelli, San Diego, CA (US);

Valentina Molteni, San Diego, CA (US);

Xiaolin Li, San Diego, CA (US);

Xiaodong Liu, San Diego, CA (US);

Juliet Nabakka, San Diego, CA (US);

Jon Loren, San Diego, CA (US);

Assignee:

IRM LLC, Hamilton, BM;

Attorneys:
Int. Cl.
CPC ...
C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 405/14 (2006.01); C07D 409/14 (2006.01); A61K 31/506 (2006.01); A61P 1/06 (2006.01); A61P 9/12 (2006.01); A61P 11/00 (2006.01); A61P 17/04 (2006.01);
U.S. Cl.
CPC ...
Abstract

The invention provides compounds of Formula (I) and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit, PDGFRα, PDGFRβ, CSF1R, Abl, BCR-Abl, CSK, JNK1, JNK2, p38, p70S6K, TGFβ, SRC, EGFR, trkB, FGFR3, Fes, Lck, Syk, RAF, MKK4, MKK6, SAPK2β, BRK, Fms, KDR, c-raf or b-raf kinases.


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