The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 16, 2012
Filed:
Dec. 01, 2011
Julian M. C. Golec, Faringdon, GB;
Paul S. Charifson, Framington, MA (US);
Jean-damien Charrier, Abingdon, GB;
Hayley Marie Binch, Encinitas, CA (US);
Julian M. C. Golec, Faringdon, GB;
Paul S. Charifson, Framington, MA (US);
Jean-Damien Charrier, Abingdon, GB;
Hayley Marie Binch, Encinitas, CA (US);
Vertex Pharmaceuticals Incorporated, Cambridge, MA (US);
Abstract
This invention provides novel compounds, and pharmaceutically acceptable derivatives thereof, that are useful as caspase inhibitors. These compounds have the general formula I: where R, R, and Rare as described herein, Ring A contains zero to two double bonds, each X is independently selected from nitrogen or carbon, at least one X in Ring A is a nitrogen, Ring A is optionally substituted as described, and may be fused to a saturated or unsaturated five to seven membered ring containing zero to three heteroatoms, and provided that when Xis a carbon, a substituent on Xis attached by an atom other than nitrogen.