The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 16, 2012
Filed:
Nov. 03, 2004
Applicants:
Sharon M. Wahl, N. Potomac, MD (US);
Nancy Vazquez-maldonado, Chevy Chase, MD (US);
Teresa Greenwell-wild, Gaithersburg, MD (US);
Inventors:
Sharon M. Wahl, N. Potomac, MD (US);
Nancy Vazquez-Maldonado, Chevy Chase, MD (US);
Teresa Greenwell-Wild, Gaithersburg, MD (US);
Assignee:
Primary Examiner:
Int. Cl.
CPC ...
A61P 31/18 (2006.01); A61K 31/192 (2006.01); A61K 38/16 (2006.01);
U.S. Cl.
CPC ...
Abstract
This invention relates to methods and compositions for the attenuation of HIV-1 replication in human cells, and especially in human macrophages. The invention particularly concerns the use of inhibitors of P21 (CDKNIA) expression to attenuate such replication. The invention particularly concerns the use of antisense P21 oligonucleotides, siRNA and/or 2-cyano-3,12-dioxooleana-1,9-dien28-oic (CDDO) to attenuate such replication.