The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 16, 2012
Filed:
Sep. 04, 2008
Desmond John Best, Essex, GB;
Sing Yeung Mak, Singapore, SG;
Barry Sidney Orlek, Essex, GB;
Geracimos Rassias, Stevenage, GB;
Pamela Joan Theobald, Essex, GB;
Desmond John Best, Essex, GB;
Sing Yeung Mak, Singapore, SG;
Barry Sidney Orlek, Essex, GB;
Geracimos Rassias, Stevenage, GB;
Pamela Joan Theobald, Essex, GB;
Glaxo Group Limited, Greenford, Middlesex, GB;
Abstract
The present invention relates to 1-(1-methylethyl)-4-{[4-(tetrahydro-2H-pyran-4-yloxy)phenyl]carbonyl}piperazine or a pharmaceutically acceptable salt thereof, in particular the hydrochloride salt thereof and crystalline forms of the hydrochloride salt; to processes for the preparation of the compound or its salt; to compositions containing it; and to its use in the treatment or prophylaxis of neurological or psychiatric diseases, such as cognitive impairment, fatigue or a sleep disorder, for example in a mammal such as a human. The compound or a salt thereof has affinity for and is an antagonist and/or inverse agonist of the histamine H3 receptor.